benchmark studies :: clinically significant change

This study is important because it demonstrates a harm reduction option, likely to be long term, for injecting heroin addicts who do not respond to optimised oral methadone...


Strang J, Metrebian N, Lintzeris N, Potts L, Carnwath C, Mayet S, Williams H, Zador D, Evers R, Groshkova T, Charles V, Martin A and Forzisi L (2010) Supervised injectable heroin or injectable methadone versus optimised oral methadone as treatment for chronic heroin addicts in England after persistent failure in orthodox treatment (RIOTT): a randomised trialLancet 375: 1885–95

DOI: 10.1016/S0140-6736(10)60349-2